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Home _Departments _Bioprocess Engineering
Bioprocess Engineering
Research Subjects BVT
Bioengineering and bioprocess engineering are multi-faceted disciplines, ranging from micro-scale processes (drug development, stem cell research, micro reactor design etc.) to small/middle scale processes (protein production, process optimization, bio-pesticides or -insecticides production, etc.) to developing large-scale plants and reactors (therapeutic production, waste-water-treatment, etc.). In our daily live all of us are in contact with biotechnology products and not only by using pharmaceuticals. Fermented food (like beer, 막걸릿or 김?belong - strictly spoken - to the field of bioprocess engineering and many products like pregnancy test (immunological assays) or strawberry flavour (bio transformations) have their origin in bioengineering.
All of those fields and processes have one thing in common: the combination of the general art of engineering with biological knowledge and aspects.

The Institute of Bioprocess Engineering of Friedrich-Alexander-University of Erlangen-Nuremberg Campus Busan wants to establish four different fields of research:
In cooperation with the Institute of Chemical Engineering of the FAU-Busan Campus the influence of ionic liquids on enzymatic reactions will be investigated. Desirable is an optimization of the stability of enzymes to elongate continuous processes, which will highly increase the space-time-yield of already established processes. Another focus will be spotted on the ionic interaction between ionic liquid and the enzyme, so that isomeric equilibriums can be influenced by interfering the active centrer of the biological catalyst. Cooperation partners : Dipl.-Ing. S. Willmes, Dr. rer. nat. M. Haumann (FAU-Busan Campus), Prof. Dr. P. Wasserscheid (Head of the Institute of Chemical Engineering, FAU Erlangen-Nuremberg, Germany), Prof. Dr. em. C. Wandrey (Institute of Biotechnology, Forschungszentrum Juelich, Germany, member of the flying faculty).
The field of protein production is a very common field of research at laboratories all over the world. Vectors for genetic transference are almost as manifold as the genetic code itself. But over the last two decades, viral vectors have gained the most popularity. Very in common are those vectors establishing transgenic plants or for protein production in insect cells using the Baculovirus expression system. As this system is widely optimized, we are aiming on constructing a new viral vector for insect cells, which shall overcome some of the weaknesses of the Baculovirus system. Besides the work with insect cells as host organisms, this project will focus on algae. For the family of algae no flexible viral vector for protein expression exists, although those organisms feature a high variety of post translational modifications. Therefore algae as host for protein production will come to the interest of pharmaceutical companies.
Cooperation partners1: Dr. rer. nat. F. Vogel (FAU-Busan), Prof. Dr. Cho Man-Gi (Dongseo University, South Korea).
As mentioned in the introduction, immunological assays belong to the field of biotechnologies. In cooperation with the German parent institute, this kind of analytical tools will be optimized by constructing a new composition of protein-antibody-protein complexes. Those complexes will enable to rise the resolution of, for example, ELIZA-systems.
Cooperation partners : Dipl.-Ing. T. Weidner, Dr.-Ing. H. Hübner (Institute of Bioprocess Engineering, FAU Erlangen-Nuremberg, Germany).

The order of the mentioned cooperation partners is not reflective to the contribution upon the project.

The last project in this row is part of the field of "reactor development". Hanging drop cultures are a common way to cultivate mammalian cells as tissue cultures. The problem behind this cultivation system is given by the unsteady nutrient supply along the process time. The nutrient composition of the media or their supply can highly affect the growth and differentiation behaviour of cells. Therefore we have already started engineering a continuous reactor for hanging drop cultivations.
The broad spectrum of different independent research fields is based on the philosophy of the German parent institute. The research of the Institute of Bioprocess Engineering (FAU Erlangen-Nuremberg, Germany), which is chaired by Prof. Dr. Rainer Buchholz, is driven by four different working groups. Regarding the topics of the groups they do not have much in common. But having people with different knowledge and different ways of thinking, based on their working fields, can lead to a cross-stimulating effect on the groups.
Cell Culture and Immobilization: Immunology (expanding encapsulated B-cells); micro reaction/cultivation systems (expansion of primary heart cells; screening of differentiation); protein expression (Baculovirus expression system, encapsulation, post translational modifications), single cell protein production
Marine Biotechnology: substance screening (antiviral, pharmaceutical active); production of unsaturated fatty acids; development of new reactor systems.
Research in this group is based on cultivations in the own developed photo bioreactor screening modules, and the scale up of those modules
Plant Biotechnology: Synthesis of antiviral substances, screening of pharmaceutical effective substances
Bioanalysis: characterisation of secondary metabolites, identifications by mass spectrometry, tracing of pathways using isotope labelled precursors, product purification, structure analyses using MALDI-Trap_Tof MSn hybride mass spectrometry.
For further information on the Institute of Bioprocess Engineering in Germany please visit the homepage: www.bvt.cbi.uni-erlangen.de